Plum ties include Chelsea v Dynamo Kyiv, Frankfurt v Inter and Arsenal v Rennes.
Arsenal, Chelsea and Internazionale were among the clubs to join Sevilla in the round of 16.
José María Giménez and Diego Godín fired late goals as Atlético prised a healthy lead to take to Turin.
Manchester City scored two late goals to secure a dramatic 3-2 win at Schalke.
Lyon produced a resolute defensive display to hold Barcelona to a goalless draw in this round of 16 opener.
There was nothing to separate Liverpool and Bayern München at Anfield.
Immovable object meets unstoppable force – Atlético welcome Cristiano Ronaldo and Co to the Spanish capital.
There are reunions aplenty when Manchester City visit Schalke – here's all you need to know.
Eager for another crack at the UEFA Champions League final, Paulo Dybala talks Cristiano Ronaldo, Massimiliano Allegri and Atlético.
When is the round of 16 draw? How will it work? Which teams will be involved? Get the lowdown.
Lyon must take on Lionel Messi and Co without suspended talisman Nabil Fekir – welcome to our in-depth guide.
Liverpool manager Jürgen Klopp renews his rivalry with Bayern – here's all you need to know.
"There's always pressure at a big club," says Liverpool defensive leader Virgil van Dijk.
"We wouldn't change it for the world" – Antoine Griezmann has learnt to love Diego Simeone's demanding style at Atlético.
"He released that striker's instinct in me," Bayern's Robert Lewandowski said as he prepared for a reunion with Jürgen Klopp.
Arsenal have to turn round a first-leg deficit against BATE Borisov, who are bidding to reach the last 16 for the first time.
Chelsea's quest to lift the trophy again continues as Malmö visit trailing 2-1 after the first leg in Sweden.
City's German midfielder is heading to his native Gelsenkirchen to take on Schalke; "I still have my best friends there," he tells UEFA.com.
Sevilla have already won three UEFA Europa League titles and are in pole position to reach the round of 16 after winning at Lazio.
Jürgen Klopp is set to face old adversaries Bayern München for the first time with Liverpool.
Chelsea are the only team with two players in the round of 32 first-leg selection; who makes the cut?
Several leading sides claimed valuable away wins in the round of 32 first legs, but Arsenal were not among them.
Tottenham dominate the first Fantasy Football Team of the Week of the round of 16.
Second-half goals from Heung-Min Son, Jan Vertonghen and Fernando Llorente left Spurs in sight of the last eight.
Sergio Ramos has racked up his 600th Real Madrid appearance – UEFA.com pays tribute.
The holders soaked up the pressure in Amsterdam before Marco Asensio's late suckerpunch snatched victory.
Gianluigi Buffon reached another UEFA Champions League landmark on Tuesday; how does he rank among the best?
Dortmund and Spurs are set to renew a very recent rivalry. We remember their first meeting.
Nicolò Zaniolo scored his first UEFA Champions League goals on Tuesday and now has the world at his feet.
Nicolò Zaniolo struck twice to give Roma the advantage but Adrián López's reply levaes the tie delicately poised.
Ajax look to refamiliarise themselves with the knockout stage, up against holders Real Madrid.
Paris condemned Manchester United to their heaviest ever home defeat in Europe.
Legacy-building head-to-heads and a first for Cristiano Ronaldo – what links European giants Ajax and Real Madrid?
"There is no margin for error." Thibaut Courtois on the pressure of being Real Madrid No1 and the changing role of a keeper.
Iker Casillas remains out in front although Cristiano Ronaldo is threatening to catch his one-time team-mate.
Aaron Ramsey will join Juventus this summer – where does he rank among Wales's European greats?
A resurgent Manchester United welcome injury-hit Paris to Old Trafford – here's all you need to know.
What lies ahead for European giants Arsenal, Celtic, Chelsea, Fenerbahçe, Galatasaray, Internazionale and Napoli?
Ole Gunnar Solskjær hopes his side can "rediscover the Manchester United way" against Paris on Tuesday.
The three-time winner on life at "historic club" Porto and his Real Madrid memories.
Cengiz Ünder talks about his first 18 months at Roma, the language barrier and making it in the UEFA Champions League.
From Canaries to Eagles and Bhoys to Pitmen, we run through the round of 32 teams' nicknames.
Europe's top scorer: is it Robert Lewandowski, Munas Dabbur, Lionel Messi or Nõmme Kalju's Liliu?